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. 2018 Apr 3;6:3. doi: 10.1186/s40170-018-0178-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CK activity and EK activity are downregulated in IDHmut glioma cells. CKα expression in the NHA (a) and U87 (b) models. c Representative ³¹P-MR assay for CK activity showing PC build-up following addition of cell lysate to a reaction mix containing choline and ATP. The inset shows the rate of PC production in the NHA model. Quantification of CK activity in the NHA (d) and U87 (e) models. f Representative ³¹P-MR assay for EK activity showing PE build-up following addition of cell lysate to a reaction mix containing ethanolamine and ATP. The inset shows the rate of PE production in the NHA model. Quantification of EK activity in the NHA (g) and U87 (h) models