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. 2018 Apr 3;6:3. doi: 10.1186/s40170-018-0178-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — 2-HG is responsible for the downregulation of PC and PE synthesis in IDHmut glioma cells. PC (a), PE (b), CKα expression (c), CK activity (d), and EK activity (e) in NHAIDHwt cells, NHAIDHwt cells incubated with 2-HG, NHAIDHmut cells, and NHAIDHmut cells treated with AGI-5198