| Indications for therapy |
| Symptomatic primary or secondary hypogonadism including late-onset hypogonadism |
| Delayed puberty in males |
| Contraindications for therapy |
| Unstable congestive heart failure |
| Polycythemia (hematocrit >50%) |
| Severe lower urinary tract symptoms (LUTS) [International Prostate Symptom Score (IPSS) >19] (refer to urology) |
| Existing or suspected prostate cancer or masses (refer to urology) |
| Infertility (refer to urology) |
| Untreated sleep apnea |
| History of cardiovascular event (heart attack, stroke, acute coronary syndrome)—authors recommend collaborative care with a physician for these patients |
