Figure 4.

C21 treatment attenuates pulmonary vascular remodeling in BLEO animals. (A–D) Representative images of α-smooth muscle actin stained pulmonary vessel wall (white arrows). (E–H) Summary data showing the improvement of muscularization by C21 in BLEO animals for the complete, 0–25, 25–50, and 50–100 μm category, respectively. Data represented in (E–H) are mean ± SEM (n = 3). ^*Indicates a p-value of ≤ 0.05, comparing BLEO animals against the controls. # Indicates a p-value of ≤ 0.05, comparing BCP and BCT vs. BLEO. @ indicates a p-value of ≤ 0.05, comparing BCP and BCT vs. control. Scale = 50 μm.