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. 2018 Mar 27;9:180. doi: 10.3389/fphys.2018.00180

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Copyright © 2018 Rathinasabapathy, Horowitz, Horton, Kumar, Gladson, Unger, Martinez, Bedse, West, Raizada, Steckelings, Sumners, Katovich and Shenoy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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C21 treatment reduces the infiltration of pulmonary macrophages in BLEO animals (A–D) Representative images of CD68⁺ macrophages. (E) Summary data showing the reduction of CD68⁺ pulmonary macrophages (red) in BLEO animals in presence of C21. Data represented in (E) is mean ± SEM (n = 3). ^*Indicates a p-value of ≤ 0.05, comparing BLEO animals against the controls. # Indicates a p-value of ≤ 0.05, comparing BCP and BCT vs. BLEO. @ indicates a p-value of ≤ 0.05, comparing BCP and BCT vs. control. Scale = 100 μm.