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. 2018 Mar 27;8:92. doi: 10.3389/fcimb.2018.00092

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Copyright © 2018 da Silva, Menezes, Kitano, Oliveira, Abreu, Souza, Heinemann, Isaac, Fraga, Serrano and Barbosa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Degradation of plasma proteins by Leptospira interrogans secreted proteases. (A) Plasma fibronectin (5 μg), (B) fibrinogen (15 μg), (C) plasminogen (5 μg), and (D) thrombin (1 μg) were incubated with supernatants of pathogenic Leptospira interrogans serovar Kennewicki strain Fromm or saprophytic Leptospira biflexa serovar Patoc strain Patoc I (0.5 μg of total secreted proteins) at 37°C for the indicated time points. Cleavage products were evaluated by SDS- polyacrylamide gel under reducing conditions. Gels were silver stained. FN, plasma fibronectin; FBG, fibrinogen; PLG, plasminogen; THB, thrombin; Sup (LPF), supernatant of Leptospira interrogans serovar Kennewicki strain Fromm; Sup (Patoc), supernatant of Leptospira biflexa serovar Patoc strain Patoc I.