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. Author manuscript; available in PMC: 2018 Apr 3.
Published in final edited form as: Curr Top Dev Biol. 2018 Feb 3;127:105–118. doi: 10.1016/bs.ctdb.2017.10.002

Figure 1.

Figure 1

Figure 1

Domain map and post-translaional modifications that influence FOXO1 & FOXO3 apoptotic activity within neurons. (A) Annotated FOXO1 protein numbered vs. the human sequence. Within the domain structure the forkhead domain is colored blue, nuclear localization signals are red, nuclear export signals are green and the transactivation domain is yellow. Modifications that promote cell death are marked with red lines, green lines mark modifications that promote survival and blue lines mark modifications with conflicting reports on survival. (B) Annotated FOXO3 protein numbered vs. the human sequence. Same color scheme as A.