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. 2018 Apr 2;150(4):521–537. doi: 10.1085/jgp.201711959

Figure 1.

Figure 1.

Ca2+ dependence of channel open probability of the three RyR isoforms. Ca2+ dependence measured by ryanodine binding to rabbit muscle preparations. (A) Data and fits by Eq. 2 in the absence of extracellular-side Mg2+. (B) Best fits in 1 mM Mg2+. Data from Murayama and Kurebayashi (2011); fit parameters listed with their Fig. 2. The dashed curve in B represents the best fit to rate constants of Ca2+ release from cardiac SR vesicles, measured with stopped-flow mixing by Sánchez et al. (2003) in the absence of Mg2+. The equation is
k=kmax[Ca2+]naKiniKanaKini+[Ca2+]naKini+[Ca2+]niKana,
with parameter values given in their Fig. 5.