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. 2018 Apr 2;150(4):521–537. doi: 10.1085/jgp.201711959

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© 2018 Ríos.

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Figure 11. — Consensus and questions. RyR1 or α, located exclusively at t–SR junctions, are activated conformationally by Ca_V1.1 (DICR). RyR3 or β, absent in most mammalian muscles, are located parajunctionally and activated by Ca²⁺ (CICR). Question marks represent the unknown role of uncoupled junctional RyR1 (C channels), the unconfirmed possibility of allosteric RyR–RyR interactions, and the evolving quest on RyR control from within the SR. Modified from Pouvreau et al. (2007).