Figure 6.

The effect of a fast Ca²⁺ buffer on calculated Ca²⁺ release flux. (A) Flux calculated by Jacquemond et al. (1991) from cytosolic Ca²⁺ transients measured in frog myofibers before and after injection of BAPTA. (B) Reference record from A with superimposed lines depicting predictions of the records that would result if BAPTA abolished inactivation (orange) or activation by Ca²⁺ (blue). The calculations of flux by Jacquemond et al. (1991) are consistent with abolition of CICR.