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. 2018 Apr 2;215(4):1245–1265. doi: 10.1084/jem.20162042

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© 2018 Carpier et al.

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Figure 5. — Rab6 and Syntaxin-16 are required for TCR-induced IL-2 production by T lymphocytes. (A–D) IL-2 production was measured in Jurkat cells activated for 6 h with Raji cells pulsed with different concentrations of SEE. (A and B) In cells expressing control or Rab6-specific shRNA, IL-2 in the supernatant (ELISA; A) or quantitative PCR of IL-2–specific cDNA (B). (C and D) In cells expressing control or Syntaxin-16–specific shRNA, IL-2 in supernatant (ELISA; C) or produced inside the cells (intracellular flow cytometry; D). *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 (two-way ANOVA; mean and SEM). Data represent five experiments (A), four experiments (B), and three experiments (C and D).