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. 2018 Apr 2;217(4):1453–1465. doi: 10.1083/jcb.201707055

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© 2018 Sun et al.

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Figure 4. — Blocking TMD topology transmission in β7 impaired agonist-promoted arrest of rolling T cells. (A and B) Adhesion of Jurkat T cells that stably expressed WT or mutant β7(L721P or L723P) on MAdCAM-1 with or without CXCL12 (A) or PMA (B) stimulation under a wall shear stress of 2 dyn/cm². Mutant integrins were compared with the WT for each condition using one-way ANOVA. (C and D) Rolling velocity of Jurkat T cells that stably expressed WT or mutant β7(L721P or L723P) on MAdCAM-1 with or without CXCL12 (C) or PMA (D) stimulation under a wall shear stress of 2 dyn/cm². Stimulated cells were compared with resting (None) for each cell line using one-way ANOVA. The numbers of cells remaining bound (A) and cell velocity (B) were analyzed. Error bars show means ± SD. n = 5. NS, P > 0.05; ***, P < 0.001.