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. 2018 Apr 2;217(4):1453–1465. doi: 10.1083/jcb.201707055

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© 2018 Sun et al.

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Figure 7. — Itgb7^L720P/L720Padult mice have reduced gut-tropic β7^high effector/activated T cells. (A) Equivalent cell surface expression of integrin αL, α4, β1, β2, and β7 and intracellular expression of kindlin 3 and talin in neonatal Itgb7^WT/WT mice and Itgb7^L720P/L720P littermates are shown. (B) Cell surface expression of β7 is reduced in 8-wk-old Itgb7^L720P/L720P compared with Itgb7^WT/WT littermates. (C) The ratio of cell surface expression of integrin β7 on effector/activated T cells (CD62L^lowCD44^high) compared with naive T cells (CD62L^highCD44^low) in 8-wk-old Itgb7^WT/WT mice and Itgb7^L720P/L720P littermates. Mean fluorescence intensities are displayed on the representative histograms. Error bars show means ± SD. **, 0.001 < P < 0.01. Teff, effector T cells.