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. 2018 Apr 2;217(4):1163–1167. doi: 10.1083/jcb.201803048

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© 2018 Rockefeller University Press

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Figure 1. — The original signal hypothesis (adapted from reference 2). (A) Illustration of the essential features of the signal hypothesis for the transfer of proteins across membranes. Signal codons after the initiation codon AUG are indicated by a zigzag region in the mRNA. The signal sequence region of the nascent chain is indicated by a dashed line. Endoproteolytic removal of the signal sequence is indicated by the presence of signal peptides (indicated by short dashed lines). (B) Model for the formation of a transient proteinaceous tunnel in the membrane through which the nascent chain is transferred.