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. 2018 Mar 12;8(4):702–710. doi: 10.1002/2211-5463.12407

Figure 3.

Figure 3

(A) ELISA quantitation of cleaved AREG from the supernatant of MEKs after overnight stimulation with either DMSO or 100 nm PMA. ND, not detected; Data represent mean ± SD. ****P < 0.0001; ns, not significant. (B) ELISA quantitation of cleaved AREG from the supernatant of MEKs after overnight stimulation with either PBS or 1 μg·mL−1 LPS. ND, not detected; Data represent mean ± SD. ****P < 0.0001; ***P < 0.001; **P < 0.01; ns, not significant. (C) Loss of ADAM17 modifies the Rhbdf2 cub/cub hair loss and ear‐punch closure phenotypes and in vitro deficiency of ADAM17 in Rhbdf2 cub/cub keratinocytes prevents stimulated secretion of AREG, together suggesting that ADAM17 is indispensible for sheddase of AREG.