Table 2.
Patient outcomes
| Characteristics | Number of Patients (%)
|
P Value | |
|---|---|---|---|
| < 75 years (n=442) |
≥ 75 years (n=330) |
||
| First recurrence site | 111 (25.1) | 88 (26.7) | 0.625 (recurrence vs. no recurrence) |
| Local recurrence | 22 (5.0) | 14 (4.2) | |
| Regional recurrence | 26 (5.9) | 18 (5.5) | |
| Distance metastases | 45 (10.2) | 35 (10.6) | |
| Simultaneous failure | 18 (4.1) | 21 (6.4) | |
| Cumulative events | 0.763 | ||
| Local recurrence | 32 (7.2) | 23 (7.0) | |
| Regional recurrence | 40 (9.0) | 34 (10.3) | |
| Distance metastases | 60 (13.6) | 55 (16.7) | |
| Median time to any recurrence, mo (min–max) | 13.6 (2.6–70.7) | 12.0 (0.7–91.9) | 0.262 |
| Median time to LR | 14.7 (4.1-60.6) | 14.4 (3.3–91.9) | |
| Median time to RR | 12.3 (2.6-70.7) | 9.5 (2.5–41.6) | |
| Median time to DM | 14.2 (2.8-68.1) | 11.7 (0.7–91.9) | |
| Death | 210 (47.5) | 190 (57.6) | 0.006 (dead vs. alive) |
| From lung cancer | 71 (33.8) | 58 (30.5) | 0.755 (cause of death) |
| From other disease | 101 (48.1) | 94 (47.9) | |
| Unknown | 38 (18.1) | 38 (20.0) | |
| Median follow-up time, mo (min–max) | 54.6 (51.3–57.8) | 55.2 (49.6–60.8) | 0.706 |
| Median PFS time, mo PFS rates, % | Not reached | Not reached | 0.419 |
| 1 year | 87.3 | 86.0 | |
| 3 years | 74.6 | 71.3 | |
| 5 years | 69.7 | 66.9 | |
| Median OS time, mo (min–max) OS rates, % | 61.2 (53.2–69.2) | 47.7 (39.6–55.9) | 0.003 |
| 1 year | 89.1 | 86.0 | |
| 3 years | 67.6 | 57.5 | |
| 5 years | 51.5 | 39.5 | |
| Median lung cancer-specific OS time, mo | 112.3 | Not reached | 0.275 |
Abbreviations: LR, local recurrence; RR, regional recurrence; DM, distant metastasis; PFS, progression-free survival; OS, overall survival.