Fig. 6. Erythrocyte uptake and clearance of Aβ and Aβ ICs in non-human primates.

Relative to the amount of Aβ available in the plasma compartment, erythrocyte uptake and clearance of Aβ inoculated into two non-human primates was significantly greater for Aβ ICs compared to Aβ alone (P < 0.001). Because erythrocyte and plasma levels at baseline differed in the animals, the data in the figure have been normalized as percent of Aβ recovered in the erythrocyte compartment relative to the amount available in the plasma compartment. Clearance into the erythrocyte compartment was rapid over the first 15 minutes after Aβ or Aβ IC injection, a characteristic of immune adherence [41]. By 20 minutes, Aβ IC values had returned to baseline, but remained elevated by some 20% relative to baseline for Aβ alone. Samples at each time point in each animal were assayed in duplicate. Standard error bars for each time point for each animal were smaller than the symbols at each time point and are not shown. For Aβ alone, mean standard error was 0.13% (range of 0.01 to 0.39). For Aβ IC, mean standard error was 0.82% (range of 0.10 to 2.81).