Figure 5.

A) Architectural complexity plot of beta-grasp domains found in eukaryotes and prokaryotes. The complexity quotient (CQ) for a given species (y-axis) is plotted against the total number of beta-grasp domain containing proteins in the same species. Species abbreviations are given next to plot points. B) Domain architectures of selected beta-grasp domains. Proteins are denoted by their gene names, species abbreviations and genbank index numbers. Proteins are not drawn to scale. The conserved cysteine clusters observed in the NPL4-N family are shown as orange ellipses. Expansion of domain abbreviations: B3, DNA-binding domain; Auxin response, auxin-responsive transcription factor domain, also called Aux-RF; OTU, OTU-like family of cysteine proteases; Znf, zinc-finger; Znf_LF, little finger family of zinc finger domains; beta-P, beta-propeller domain; X, previously uncharacterized BofC C-terminal domain. Species abbreviations are as follows: Aaeo, Aquifex aeolicus; Ath, Arabidopsis thaliana; Bfra, Bacteroides fragilis; Cele, Caenorhabditis elegans; Cneo, Cryptococcus neoformans; Cpneu, Chlamydophila pneumoniae.; Cpar, Cryptosporidium parva; Ctet, Clostridium tetani; Ctep, Chlorobium tepidum; Ddis, Dictyostelium discoideum; Dmel, Drosophila melonogaster; Drad, Deinococcus radiodurans; Drer, Danio rerio; Ecol, Escherichia cioli; Ehis, Entamoeba histolytica; Glam, Giardia lamblia; Hpyl, Helicobacter pylori; Hsap, Homo sapiens; Lmaj, Leishmania major; Mpne, Mycoplasma pneumoniae; Msp., Mesorhizobium sp.; Mtub, Mycobacterium tuberculosis; Ncra, Neurospora crassa; Nmen, Neisseria meningitides; Nsp., Nostoc sp.; Otau, Ostreococcus tauri; Pfal, Plasmodium falciparum; Rnor, Rattus norvegicus; Save, Streptomyces avermitilis; Scer, Saccharomyces cerevisiae; Spom, Schizosaccharomyces pombe; Ssp., Synecococcus sp.; Tcru, Trypanosoma cruzi; Tden, Treponema denticola; Tmar, Thermotoga maritima; Tthe, Tetrahymena thermophila; Tvag, Trichomonas vaginalis; Uma, Ustilago maydis; Vcho, Vibrio cholerae.