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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Mar 16;498(4):1022–1027. doi: 10.1016/j.bbrc.2018.03.108

Figure 4. Model.

Figure 4

(A–D) Models how inorganic phosphate inhibits Dicer-2 from processing hairpin RNAs and how Loqs-PD removes this inhibitory effect. Models are shown for (A) Dicer-2 alone, (B) Dicer-2 + phosphate, (C) Dicer-2 + Loqs-PD, and (D) Dicer-2 + phosphate + Loqs-PD. The background colors of the panels (A-D) correspond to the colors used in Figures 2 and 3.