Figure 7. Schematic model of shared program: paligenosis.

Data presented in the paper suggest that differentiated cells revert to a regenerative/proliferative state via a program involving stepwise progression through three stages. Progression can be blocked at intervening checkpoints. The potential context‐independent nature of this sequence of structural‐energetic changes suggests that it is available to differentiated cells in multiple organs and species. We have termed this general program of differentiated cells acquiring regenerative potential “paligenosis”.