Table 1.

Macroscopic and histopathological evaluation of the inflammatory phenotype in kindlin 1^(−/−) and kindlin 2^(−/−) vs. wild-type mice after 3 days of tamoxifen exposure [n = 6]. The data are shown as the mean ± SD or the median [range].

	Wild-type	Kindlin 1(−/−)	kindlin 2(−/−)	Kindlin 1(−/−) + PCa	Kindlin 2(−/−) + PC
Macroscopic colitis score	0 [0–1]	8 [8–9]	10 [8–11]	1.5 [1–3]	2 [1–3]
Stool scoreb	0 [0–0]	4 [3–5]	4 [3–5]	0.5 [0–1]	2 [1–3]
Colon weight faecal content [g]	0.226 ± 0.02	0.415 ± 0.01	0.462 ± 0.01	0.309 ± 0.01	0.278 ± 0.09
Colon weight scorec	0 [0–0]	2 [2–2]	3 [2–3]	1 [1–2]	1 [1–1]
Colon length [cm]	4.8 ± 0.3	3.7 ± 0.2	3.5 ± 0.2	4.9 ± 0.3	4.7 ± 0.4
Colon length scored	0 [0–1]	2 [2–3]	3 [2–3]	0 [0–0]	0.5 [0–1]
P [total score vs. wild-type]		0.003	0.003	0.011	0.007
P [total score vs. no PC]				0.003	0.003
Histopathological colitis score	0 [0–0]	9 [9–10]	9.5 [7–10]	3 [1–3]	2 [2–4]
Extent of inflammatione	0 [0–0]	2 [1–2]	2 [1–2]	0 [0–1]	0 [0–1]
Crypt architecturef	0 [0–0]	2 [2–2]	2 [2–2]	1 [1–2]	1 [1–2]
Hyperaemia/oedemag	0 [0–0]	3 [2–3]	3 [2–3]	0 [0–1]	0.5 [0–1]
Immunocyte infiltrationh	0 [0–0]	3 [2–3]	3 [2–3]	0.5 [0–1]	0 [0–1]
P [total score vs. wild-type]		0.002	0.002	0.002	0.002
P [total score vs. no PC]				0.003	0.003
Major colitis score [macroscopic & histopathological score]	0 [0–1]	18 [17–18]	19 [18–20]	4 [4–5]	4 [3–6]
P [total score vs. wild-type]		0.003	0.003	0.003	0.003
P [total score vs. no PC]				0.002	0.002

^aPC = phosphatidylcholine. ^bStool score: 0 = normal, 1 = loosely shaped, 2 = amorphous, sticky, 3 = diarrhoea, +1 for blood. ^cColon weight score: 0 = <10%, 1 = 10–50%, 2 = >50–100%, 3 = >100–150%, 4 = >150% weight gain compared to the wild-type mean. ^dColon length score: 0 = <5%, 1 = 5–14%, 2 = 15–24%, 3 = 25–35%, 4 = >35% shortening compared to the wild-type mean. ^eExtent of inflammation: 0 = no inflammation, 1 = mucosa, 2 = mucosa and submucosa. ^fCrypt architecture: 0 = intact, 1 = regenerative, 2 = destroyed. ^gHyperaemia/oedema: 0 = none, 1 = discrete, 2 = moderate, 3 = severe. ^hImmunocyte infiltration: 0 = none, 1 = discrete, 2 = moderate, 3 = severe.