Table 3.

Total cortisol concentrations and normal response to ACTH challenge

Parameter, n/Na [%]	Budesonide MMX 9 mg n = 255	Placebo n = 255
Total cortisol > 5 µg/dlb
Baseline	249/255 [97.6]	241/255 [94.5]
Week 2	146/244 [59.8]	237/249 [95.2]
Week 4	144/241 [59.8]	233/242 [96.3]
Week 8	150/225 [66.7]	231/236 [97.9]
Normal response to ACTH challengec
Baseline	222/248 [89.5]	223/254 [87.8]
Week 8	119/224 [53.1]	202/236 [85.6]

ACTH, adrenocorticotrophic hormone; MMX, multimatrix.

^aDenominator N is the number of patients with a value at each given week during the study.

^bLower limit of normal.

^cDefined as increase from baseline in plasma cortisol concentration > 7 µg/dl, or plasma cortisol concentration > 18 µg/dl 30 min after ACTH challenge.