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. 2016 Dec 15;11(6):751–760. doi: 10.1093/ecco-jcc/jjw212

Figure 3.

Figure 3.

Colonic M cell induction by dextran sodium sulphate [DSS] is absent in TNFR2 but not TNFR1 knockout mice. a. DSS treatment has no marked effect on the development and organisation of Peyer’s patch B cell follicles [cyan] and associated M cells [red] in TNFR1 and TNFR2 knockout mice. Scale bar: 40 µm. b. DSS treatment induces infiltrates in the colon with variable organisation of B cells [cyan]. M cells [red] are found associated with infiltrates although there are fewer M cells found in TNFR2 knockout mice. Scale bar: 40 µm. c. M cell counts in a histological survey of colon [24 images from each mouse] show significant increases in M cell counts in control and TNFR1 knockout mice, but no significant increase above background in TNFR2 knockout mice. Results are representative of three independent replicate studies. [*P < 0.05; **P < 0.005; ns, not significant].