Figure 4.

Dextran sodium sulphate [DSS] induces lamina propria RANKL expression in PP and colon. a. Immunostaining of Peyer’s patches [PP] for receptor activator of nuclear factor kappa-B ligand [RANKL] [orange] shows expression in stromal cells, with apparent increases in DSS-treated mice, though no apparent effect on M cells [red]. Scale bar: 40 µm. b. DSS-induced colonic infiltrates show induction of lamina propria stromal cell RANKL expression [orange], with apparent increase in RANKL signal relative to constitutive colonic patch levels. M cells in red. Scale bar: 40 µm.