Figure 1.

NTPDase2 and -3 expression in normal murine colon and experimental colitis. A. NTPDase2 is expressed in the ganglia of the myenteric plexus [*], scarcely in fibres of the muscularis propria, and more strongly in thin elongated structures of the submucosa and lamina propria [arrows]. B. NTPDase3 expression is also localised in the ganglion cells, with an abundant expression in cells and fibres throughout the smooth muscle layer [arrow heads] and little expression in the submucosa and lamina propria. C, D. NTPDase2 and -3 expression were absent in Entpd2 [C] and Entpd3 [D] null mice, respectively. After 7 days of dextran sodium sulphate [DSS]induction. E, F. NTPDase2 and -3 expression in the colon after DSS induction. The scale bar represents 200 µm.