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Overview of cytokines signalling via the JAK-STAT pathway. JAK inhibitors interfere with a number of key pro-inflammatory cytokines involved in the pathogenesis of inflammatory bowel disease [IBD]. IFN, interferon; IL, interleukin; GM-CSF, granulocyte macrophage colony-stimulating factor; OSM oncostatin M; GH growth hormone; EPO erythropoietin; TPO thrombopoietin. Adapted with permission from Rawlings et al., J Cell Sci 2004;117:1281–3.
