Table 1.
Evidence for partitioning from loss of function studies
| Gene | Tissue | FA partitioning information | Phenotype | References |
|---|---|---|---|---|
| Acsl1 KO | Liver-specific | Decreased FA incorporation into TAG & oxidation | None | (103) |
| Adipose-specific | Decreased FA oxidation | Increased adipose mass; defective thermogenesis | (37) | |
| Multi-tissue- heart | Decreased FA oxidation | None | (38) | |
| Heart-specific | Decreased FA oxidation | None | (38) | |
| Macrophage-specific | Altered 20:4 metabolism and PGE2 production | Protects macrophages against diabetes-mediated inflammation | (84) | |
| Endothelial cell- specific | No information | None | (106) | |
| Acsl3 KD | Rat hepatocytes | Glycerolipid synthesis on lipid droplets? Regulation of transcription factors |
__ | (11) |
| Acsl4 KD | Cultured cells, various | Altered eicosanoid metabolism | Human X-linked mental retardation | (91, 93) |
| Acsl5 KD | Primary hepatocytes | Decreased FA incorporation into glycerolipids and cholesterol esters | Decreased lipid droplet formation | (10) |
| Acsl5 KO | Total KO | No information | None | (129) |
| Acsl6 KD | Neuroblastoma cells | 22:6ω3 metabolism? | Inhibited neurite outgrowth | (86) |
| Fatp1/Acsvl4 KO | Skeletal muscle, BAT, L6E9 cells | Decreased FA oxidation | Defective thermogenesis | (204) |
| Retina | ? Decreased FA oxidation | Accelerated retinal ageing | (17) | |
| Fatp2/Acsvl1 KO | Total KO | ? Decreased oxidation of 24:0 | None | (135) |
| Fatp3/Acsvl3 KD | Glioma | No information | Decreased anchorage-dependent growth | (157) |
| Fatp4/Acsvl5 KO | Human mutation | Decreased type II diester wax in the sebum | Ichthyosis prematurity syndrome | (108) |
| Keratinocytes | Decreased long-chain ceramides | Postnatal restrictive skin | (137) | |
| Fatp5/Acsvl6 KO | Gall bladder bile | Decreased conjugated bile acids | Low weight gain on a high fat diet | (70) |
| Fatp6/Acsvl2 | --- | No information | --- | --- |
| AcsBg1 KD | Neuro2a cells | Decreased β-oxidation | --- | (156) |
| AcsBg1 KO | Various tissues | Increased amounts of some long-chain fatty acids | None | (172, 191) |
| AcsBg2 | --- | No information | --- | --- |