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. Author manuscript; available in PMC: 2018 Nov 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2017 Jul 25;23(11):1887–1894. doi: 10.1016/j.bbmt.2017.07.014

Table 5.

Outcomes of patients receiving second transplant by patient groups

OS HR 95% CI P
Same donor as first (v. different donor) 2.31 0.77 6.92 0.16
Performed 2005–2009 (v. 2010–2015) 1.82 0.65 5.0 0.28
Age > 45 (v. <45) 1.8 0.73 4.42 0.19
Refractory or Progressive Disease (v. CR or PR) 2.56 1.03 6.25 0.06
Relapse diagnosed within 6 months (v. > 6 months) 2.49 1.0 6.2 0.07
Acute GVHD from first transplant (v. no GVHD) 2.12 0.87 5.17 0.11
Second graft contained new haplotype (v. no new haplotype) 0.36 0.14 0.9 0.02
EFS
Same donor as first (v. different donor) 1.54 0.52 4.5 0.46
Performed 2005–2009 (v. 2010–2015) 1.89 0.2 1.44 0.25
Age > 45 (v. <45) 2.32 0.99 5.44 0.05
Refractory or Progressive Disease (v. CR or PR) 2.44 1 5.88 0.07
Relapse diagnosed within 6 months (v. > 6 months) 2.53 1.03 6.22 0.06
Acute GVHD from first transplant (v. no GVHD) 1.50 0.65 3.44 0.35
Second graft contained new haplotype (v. no new haplotype) 0.50 0.22 1.14 0.09
Cumulative Incidence of Relapse
Same donor as first (v. different donor) 0.76 0.13 4.51 0.77
Performed 2005–2009 (v. 2010–2015) 1.11 0.23 5.26 0.89
Age > 45 (v. <45) 5.29 1.13 24.74 0.03
Refractory or Progressive Disease (v. CR or PR) 1.67 0.45 6.25 0.44
Relapse diagnosed within 6 months (v. > 6 months) 1.43 0.38 5.41 0.59
Acute GVHD from first transplant (v. no GVHD) 0.44 0.1 1.87 0.27
Second graft contained new haplotype (v. no new haplotype) 0.81 0.25 2.59 0.73
Cumulative Incidence of Non-Relapse Mortality
Same donor as first (v. different donor) 2.62 1.02 6.71 0.05
Performed 2005–2009 (v. 2010–2015) 1.79 0.44 7.14 0.42
Age > 45 (v. <45) 1.09 0.38 3.18 0.87
Refractory or Progressive Disease (v. CR or PR) 2.08 0.66 6.67 0.21
Relapse diagnosed within 6 months (v. > 6 months) 2.09 0.61 7.2 0.24
Acute GVHD from first transplant (v. no GVHD) 3.44 1.19 9.94 0.02
Second graft contained new haplotype (v. no new haplotype) 0.4 0.12 1.32 0.13