Table 4A.

Association between prevalent and interim atrial fibrillation and annual change in neuropsychological test performance (Interim AF N=140: Original=31; Offspring=109).

Cognitive Measure	Model 1*			Model 2**			Cohort Interaction p
	β	SE	p	β	SE	p
Visual Reproduction: Immediate Recall
noAF	Ref			Ref			0.76
prevAF	0.01	0.07	0.856	−0.01	0.08	0.897
intAF	−0.009	0.06	0.878	−0.03	0.06	0.573
Visual Reproduction: Delayed Recall
noAF	Ref			Ref			0.86
prevAF	−0.07	0.08	0.371	−0.10	0.08	0.221
intAF	−0.04	0.06	0.454	−0.07	0.06	0.267
Similarities (abstract reasoning)
noAF	Ref			Ref			0.098
prevAF	−0.06	0.09	0.503	−0.004	0.10	0.964
intAF	0.05	0.07	0.467	0.02	0.07	0.737
Hooper Visual Organization test
noAF	Ref			Ref			0.13
prevAF	−0.07	0.07	0.367	−0.02	0.08	0.802
intAF	−0.11	0.06	0.050	−0.09	0.06	0.129
Trail Making Test – A
noAF	Ref			Ref			0.66
prevAF	−0.03	0.02	0.075	−0.01	0.02	0.548
intAF	0.008	0.01	0.514	0.009	0.01	0.463
Trail Making Test – (B-A)
noAF	Ref			Ref			<0.001
prevAF	−0.25	0.06	<0.001	−0.31	0.06	<0.001
intAF	−0.08	0.04	0.071	−0.10	0.04	0.03

^*Adjusted for age, sex, education, time between baseline examination and NP testing, and cohort.

^**Additional adjustments for systolic BP, diastolic BP, antihypertensive medications, myocardial infarction and heart failure, smoking status, and ApoE ε4.