Table 2.
Top 100 probe sets differentially expressed between acute pyelonephritis and normal controls
| Rank | Name | Entrez ID | Gene Symbol | Fold change | Adjusted P-Value (q-value) | Dysregulated after endotoxin challenge in the same direction [14] |
|---|---|---|---|---|---|---|
| 1 | Family with sequence similarity 20, member A | 54757 | FAM20A | 5.74 | 1.80E-10 | |
| 2 | Family with sequence similarity 20, member A | 54757 | FAM20A | 3.21 | 2.83E-08 | |
| 3 | Family with sequence similarity 20, member A | 54757 | FAM20A | 5.78 | 2.83E-08 | |
| 4 | Methyltransferase like 7B | 196410 | METTL7B | 10.71 | 6.92E-07 | |
| 5 | Ankyrin repeat domain 22 | 118932 | ANKRD22 | 7.29 | 8.80E-07 | |
| 6 | Kiaa1632 | 57724 | KIAA1632 | 1.69 | 1.64E-06 | |
| 7 | Fc fragment of IgG, high-affinity Ia, receptor (CD64) | 2209 | FCGR1A | 1.97 | 2.36E-06 | |
| 8 | Dual-specificity phosphatase 3 | 1845 | DUSP3 | 2.16 | 2.47E-06 | Yes |
| 9 | Proline-serine-threonine phosphatase-interacting protein 2 | 9050 | PSTPIP2 | 1.79 | 2.44E-05 | Yes |
| 10 | Glucosamine (N-acetyl)-6-sulfatase | 2799 | GNS | 1.69 | 2.44E-05 | Yes |
| 11 | Guanylate-binding protein 1, IFN-inducible, 67 kDa | 2633 | GBP1 | 4.33 | 2.44E-05 | Yes |
| 12 | Erythrocyte membrane protein band 4.1-like 5 | 57669 | EPB41L5 | 2.93 | 2.44E-05 | |
| 13 | Feline leukemia virus subgroup C cellular receptor family, member 2 | 55640 | FLVCR2 | 2.33 | 2.44E-05 | |
| 14 | Dual-specificity phosphatase 3 | 1845 | DUSP3 | 1.72 | 3.82E-05 | Yes |
| 15 | Kelch-like 3 (Drosophila) | 26249 | KLHL3 | −2.20 | 5.00E-05 | |
| 16 | Lipoma HMGIC fusion partner-like 2 | 10184 | LHFPL2 | 2.36 | 5.75E-05 | |
| 17 | Sortilin 1 | 6272 | SORT1 | 1.96 | 7.22E-05 | |
| 18 | Membrane-spanning 4-domains, subfamily A, member 4 | 51338 | MS4A4A | 3.59 | 7.22E-05 | Yes |
| 19 | Membrane-spanning 4-domains, subfamily A, member 4 | 51338 | MS4A4A | 3.86 | 7.22E-05 | Yes |
| 20 | MAPK kinase 6 | 5608 | MAP2K6 | 1.93 | 7.22E-05 | Yes |
| 21 | Membrane-spanning 4-domains, subfamily A, member 4 | 51338 | MS4A4A | 2.89 | 7.22E-05 | Yes |
| 22 | Apolipoprotein L, 6 | 80830 | APOL6 | 2.60 | 8.22E-05 | |
| 23 | Cornichon homolog 4 (Drosophila) | 29097 | CNIH4 | 2.19 | 8.34E-05 | Yes |
| 24 | ETS variant 7 | 51513 | ETV7 | 10.65 | 8.79E-05 | |
| 25 | TRAF-interacting protein with forkhead-associated domain | 92610 | TIFA | 2.96 | 9.07E-05 | |
| 26 | Acyl-Coenzyme A oxidase 2, branched chain | 8309 | ACOX2 | 1.84 | 9.07E-05 | |
| 27 | Fc fragment of IgG, high affinity Ib, receptor (CD64) | 2210 | FCGR1B | 1.64 | 9.37E-05 | Yes |
| 28 | Family with sequence similarity 89, member A | 375061 | FAM89A | 1.91 | 9.37E-05 | |
| 29 | Tumor protein p53 inducible protein 3 | 9540 | TP53I3 | 1.77 | 9.48E-05 | Yes |
| 30 | Pseudo-uridylate synthase 3 | 83480 | PUS3 | 1.65 | 0.00011 | |
| 31 | Basic leucine zipper transcription factor, ATF-like 2 | 116071 | BATF2 | 5.42 | 0.00012 | |
| 32 | Basic leucine zipper transcription factor, ATF-like | 10538 | BATF | 1.84 | 0.00012 | Yes |
| 33 | Apolipoprotein L, 6 | 80830 | APOL6 | 2.56 | 0.00012 | |
| 34 | Guanylate-binding protein 1, IFN-inducible, 67 kDa | 2633 | GBP1 | 2.89 | 0.00012 | Yes |
| 35 | Dual-specificity phosphatase 3 | 1845 | DUSP3 | 1.83 | 0.00013 | Yes |
| 36 | Alkaline ceramidase 3 | 55331 | ACER3 | 1.94 | 0.00013 | |
| 37 | Similar to hcg2041270 | 344887 | LOC344887 | 1.64 | 0.00013 | |
| 38 | Chromosome 13 open reading frame 15 | 28984 | C13orf15 | −2.52 | 0.00014 | |
| 39 | ER lipid raft-associated 1 | 10613 | ERLIN1 | 1.65 | 0.00015 | Yes |
| 40 | Kynureninase (L-kynurenine hydrolase) | 8942 | KYNU | 1.94 | 0.00015 | |
| 41 | CD274 molecule | 29126 | CD274 | 3.22 | 0.00015 | |
| 42 | Guanylate-binding protein 1, IFN-inducible, 67 kDa | 2633 | GBP1 | 3.11 | 0.00016 | Yes |
| 43 | IL-23, α subunit p19 | 51561 | IL23A | −1.76 | 0.00017 | |
| 44 | Methionine sulfoxide reductase B2 | 22921 | MSRB2 | 1.70 | 0.00018 | Yes |
| 45 | SH3-binding domain kinase 1 | 388228 | SBK1 | −1.61 | 0.00018 | |
| 46 | Pleckstrin homology domain containing, family G (with rhogef domain) member 3 | 26030 | PLEKHG3 | −1.68 | 0.00019 | |
| 47 | Cyclin B1 interacting protein 1 | 57820 | CCNB1IP1 | −1.67 | 0.00019 | |
| 48 | MARCKS-like 1 | 65108 | MARCKSL1 | −1.61 | 0.00019 | |
| 49 | G-protein-coupled receptor 107 | 57720 | GPR107 | 1.77 | 0.00019 | Yes |
| 50 | Guanylate-binding protein 1, IFN-inducible, 67 kDa | 2633 | GBP1 | 2.89 | 0.00021 | Yes |
| 51 | Kynureninase (L-kynurenine hydrolase) | 8942 | KYNU | 2.11 | 0.00022 | |
| 52 | Fc fragment of IgG-binding protein | 8857 | FCGBP | −2.10 | 0.00024 | |
| 53 | G-protein-coupled receptor 84 | 53831 | GPR84 | 4.13 | 0.00024 | |
| 54 | Ankyrin repeat domain 22 | 118932 | ANKRD22 | 3.89 | 0.00025 | |
| 55 | Kiaa0748 | 9840 | KIAA0748 | −1.80 | 0.00025 | |
| 56 | Hypothetical protein LOC284023 | 284023 | LOC284023 | −1.59 | 0.00025 | |
| 57 | Cholesteryl ester transfer protein, plasma | 1071 | CETP | 2.30 | 0.00026 | |
| 58 | ATP-grasp domain containing 1 | 57571 | ATPGD1 | −2.06 | 0.00026 | |
| 59 | T-cell receptor δ locus | 6964 | TRD@ | −2.11 | 0.00027 | |
| 60 | Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | 9861 | PSMD6 | 1.59 | 0.00027 | |
| 61 | Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 634 | CEACAM1 | 2.22 | 0.00027 | Yes |
| 62 | Oleoyl-ACP hydrolase | 55301 | OLAH | 3.47 | 0.00028 | Yes |
| 63 | Growth arrest-specific 7 | 8522 | GAS7 | 1.87 | 0.00031 | Yes |
| 64 | Leucine-rich repeat neuronal 3 | 54674 | LRRN3 | −3.49 | 0.00033 | |
| 65 | Poly(A)-binding protein interacting protein 2B | 400961 | PAIP2B | −1.62 | 0.00033 | |
| 66 | Leucine-rich repeat neuronal 3 | 54674 | LRRN3 | −3.32 | 0.00033 | |
| 67 | Chromosome 6 open reading frame 150 | 115004 | C6orf150 | 2.40 | 0.00034 | |
| 68 | Transmembrane protein 204 | 79652 | TMEM204 | −2.09 | 0.00036 | Yes |
| 69 | Multiple C2 domains, transmembrane 1 | 79772 | MCTP1 | 1.70 | 0.00036 | Yes |
| 70 | Kynureninase (L-kynurenine hydrolase) | 8942 | KYNU | 1.86 | 0.00036 | |
| 71 | Plexin domain containing 1 | 57125 | PLXDC1 | −2.29 | 0.00036 | |
| 72 | Phosphatidylinositol glycan anchor biosynthesis, class L | 9487 | PIGL | −2.56 | 0.00036 | |
| 73 | Cytochrome P450, family 1, subfamily B, polypeptide 1 | 1545 | CYP1B1 | 2.19 | 0.00036 | Yes |
| 74 | CD6 molecule | 923 | CD6 | −1.85 | 0.00042 | Yes |
| 75 | Phosphodiesterase 9A | 5152 | PDE9A | −2.11 | 0.00043 | |
| 76 | Filamin B β | 2317 | FLNB | −1.51 | 0.00043 | |
| 77 | MTERF domain containing 3 | 80298 | MTERFD3 | −1.72 | 0.00045 | |
| 78 | N-myristoyltransferase 2 | 9397 | NMT2 | −1.95 | 0.00045 | Yes |
| 79 | RCAN family member 3 | 11123 | RCAN3 | −2.23 | 0.00046 | Yes |
| 80 | Macrophage receptor with collagenous structure | 8685 | MARCO | 2.27 | 0.00049 | Yes |
| 81 | TRAF2- and NCK-interacting kinase | 23043 | TNIK | −1.64 | 0.00049 | |
| 82 | Potassium voltage-gated channel, subfamily H (EAG-related), member 7 | 90134 | KCNH7 | 1.87 | 0.00050 | |
| 83 | Non-protein coding RNA 219 | 114915 | NCRNA00219 | −1.65 | 0.00050 | |
| 84 | Dehydrogenase/reductase (SDR family) member 9 | 10170 | DHRS9 | 2.36 | 0.00051 | |
| 85 | Lactamase β | 114294 | LACTB | 1.81 | 0.00051 | |
| 86 | KCNE1-like | 23630 | KCNE1L | 1.94 | 0.00052 | |
| 87 | Dehydrogenase/reductase (SDR family) member 9 | 10170 | DHRS9 | 2.31 | 0.00054 | |
| 88 | F-box protein 6 | 26270 | FBXO6 | 2.34 | 0.00055 | |
| 89 | Zinc finger protein 638 | 27332 | ZNF638 | −1.73 | 0.00055 | |
| 90 | RAR-related orphan receptor A | 6095 | RORA | −1.58 | 0.00055 | Yes |
| 91 | CD247 molecule | 919 | CD247 | −1.73 | 0.00058 | Yes |
| 92 | ETS variant 7 | 51513 | ETV7 | 5.64 | 0.00059 | |
| 93 | Noggin | 9241 | NOG | −3.08 | 0.00060 | |
| 94 | Methionine sulfoxide reductase B2 | 22921 | MSRB2 | 1.63 | 0.00060 | Yes |
| 95 | TRAF-interacting protein with forkhead-associated domain | 92610 | TIFA | 1.68 | 0.00060 | |
| 96 | Kiaa1632 | 57724 | KIAA1632 | 1.58 | 0.00060 | |
| 97 | DNA damage-regulated autophagy modulator 1 | 55332 | DRAM1 | 1.95 | 0.00060 | Yes |
| 98 | Solute carrier family 16, member 10 (aromatic amino acid transporter) | 117247 | SLC16A10 | −2.40 | 0.00060 | |
| 99 | Lymphocyte-specific protein tyrosine kinase | 3932 | LCK | −1.82 | 0.00061 | Yes |
| 100 | WAS protein family, member 1 | 8936 | WASF1 | 1.91 | 0.00061 |
Up-regulation in acute pyelonephritis in pregnancy is shown with positive values, whereas down-regulation is depicted with negative values.