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. Author manuscript; available in PMC: 2018 Apr 3.
Published in final edited form as: J Matern Fetal Neonatal Med. 2013 Dec 16;27(8):757–769. doi: 10.3109/14767058.2013.844123

Table I.

Performance of IL-6, MMP-8, and the MR score for the detection of intra-amniotic inflammation and infection (defined as AF WBC count >100 cells/mm3 and a positive AF culture, respectively) as originally reported in reference [197].

Biomarker Intra-amniotic inflammation Intra-amniotic infection
Sensitivity (%) [95% CI] Specificity (%) [95% CI] Sensitivity (%) [95% CI] Specificity (%) [95% CI]
MR score ≥ 3 93.0 [84.1–97.4] 92.4 [89.2–94.0] 79.5 [68.4–87.8] 85.6 [81.7–88.5]
IL-6 >11.4 ng/mL 45.0 [34.5–52.4] 94.8 [91.2–97.4] 45.2 [36.6–52.9] 61.9 [44.7–77.3]
MMP-8 >23 ng/mL 92.9 [82.5–97.5] 66.7 [62.9–68.3] 90.7 [79.9–96.2] 65.0 [61.3–67.0]

MR score: Mass restricted score; IL-6: Interleukin 6; MMP-8: Matrix metalloproteinase 8. Source reference [197].