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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: DNA Repair (Amst). 2017 Oct 10;60:29–39. doi: 10.1016/j.dnarep.2017.10.002

Figure 2. Chemical structures and activity of DNA ligase inhibitors identified by computer aided drug design and their derivatives.

Figure 2

A. Structures and selectivity of three previously described small-molecule inhibitors of human DNA ligases are shown. B. Chemical structures of L82 derivatives that are grouped based on their selectivity for LigI (inhibit LigI more than LigIII by at least 20% and inhibit LigI by at least 40%), selective for LigIII (inhibit LigIII more than LigI by at least 10% and inhibit LigIII by at least 15%)or have similar activity against LigI and LigIII, C. Compounds that have less than 40% activity against both enzymes.