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. 2018 Jan 9;243(6):554–562. doi: 10.1177/1535370217752351

Figure 1.

Figure 1.

A proposed model for defective mitophagy in neurodegenerative diseases. Schematic shows that the constitutively elevated ISG15 pathway may inhibit the ubiquitin pathway (polyubiquitination) and consequently ubiquitin-dependent mitophagy in neurodegenerative diseases.