Table 1.

STIM1 interacting proteins.

Binding Protein	Identity of binding protein	Cell type/in vitro method	Reference
Cytoskeletal/cell surface
EB1, EB2, and EB3	Microtubule binding proteins	HEK 293, HeLa	58
PI(4,5)P2	Membrane phospholipid	Lipid-binding assay	59
GluA1 and GluA2	AMPA receptor subunit	Hippocampal neurons, rat cortical neurons	60,61
PMCA	PM ATPase that pumps Ca2+ out of the cell	HEK293	62
SOCE proteins
STIM2	ER Ca2+ sensor	HEK 293, HEK 293T, Human platelets, HeLa, NIH 3T3	63–65
Orai1	CRAC channel	Human Platelets, rat cortical neurons, mouse dendritic cells, HEK 293, MEG-01, HeLa, parathyroid adenoma tissues, Xenopus oocytes	63,66–72
Orai2	Store-operated ion channel	Mouse dendritic cells, HEK293	44,66
Orai3	Store-operated ion channel	HEK293	44
TRPC1, TRPC4, TRPC5	Non-selective cation channels	Human platelets, parathyroid adenoma tissues, SY5Y neuroblastoma cells, HEK293	71,73–76
Nuclear transport
Exportin1	Nuclear export	HEK 293T	62,77
Transportin1	Nuclear import	HEK 293T	77
ER proteins
IP3R1 and IP3R3	ER Ca2+ channels	BAECs, MDCK, Xenopus oocytes	78,79,72
SERCA3, SERCA2b	ER Ca2+ ATPase	Human Platelets, Xenopus oocytes	62,63
Calnexin	ER chaperone/MAM protein	HEK293T	77
Calsequestrin1	Ca2+ buffering	HEK293	80
SARAF	Negative regulator of SOCE	MEG-01	81
STIMATE (TMEM110)	ER multi-transmembrane protein	HEK293	54
TMEM203	ER resident regulator of Ca2+ homeostasis	HEK293	82
SPPL3	ER membrane protein of the aspartyl protease family	HEK293T	83
Junctate	Ca2+ sensing ER protein	HeLa	52
Others
SUR1	KATP channel subunit	HEK293T, mouse islets	84
Cav1.2 and Cav1.3	Voltage dependent Ca2+ channels	HEK293, HEK293T, SY5Y neuroblastoma cells, hippocampal neurons	74,85,86
Calmodulin	Ca2+ binding protein	CaM binding assay, isothermal titration calorimetry	59,87
AKAP	Scaffold protein	Hippocampal neurons	60
rPKA and cPKA	PKA subunits	Hippocampal neurons	60
PRKAA2	Energy sensor	HEK 293T	88
CRACR2A	Cytosolic Ca2+ sensing protein	HeLa	51
POST (TMEM110)	ER-resident membrane protein	HEK 293	62
Junctophilin-4	Contribute to the formation of junctional membrane complexes	HEK 293	56
α-SNAP	Cytosolic protein involved in intracellular trafficking and fusion of vesicles	HEK 293	57
Golli	Myelin basic protein	HeLa	89