Figure 2.

Hydronephrosis observed in Fryl^−/− mouse. (a) Representative kidneys with hydronephrosis from one-year-old female mice are shown. (b and c) Histopathologic observation for right kidney (b) and left kidney (c). Normal looking kidneys also showed chronic progressive nephropathy as described in the text. There was no tissue with obvious pathologic changes other than kidney of Fryl^−/− mouse. Spinal cord (d and e) and large intestine (f and g) were shown as representative tissues. (d) and (e): Fryl^+/+; (f) and (g): Fryl^−/−. Magnifications: 100× for (b)–(d); 400× for (f) and (g). (A color version of this figure is available in the online journal.)