Table 5.

Pain-related cerebral activation, Pain > Baseline, of all the subjects (HC + CP).

Name of ROIs	Side	Peak coordinates			t	p	Size (mm3)
		x	y	z
Positive activation
Superior parietal lobule/Angular gyrus/Supramarginal gyrus	R	42	−46	43	8.14	<0.000001	21634
Premotor cortex and SMA	L/R	3	5	49	7.83	<0.000001	54720
Primary sensory and motor cortex/Angular gyrus/Supramarginal gyrus/Associative visual cortex	L
Anterior insular/Pars opercularis/Premotor cortex	R	54	8	4	7.65	<0.000001	4703
	L	−30	17	10	7.33	<0.000001	9024
Thalamus/Red Nucleus/PAG	R	6	−19	−2	5.52	0.000004	777
dlPFC	R	24	47	22	4.65	0.000051	1616
	L	−27	38	22	4.81	0.000033	929
Fusiform gyrus	R	51	−55	−8	5.18	0.000011	1851
	L	−45	−67	4	5.35	0.000007	2310
Thalamus/Midbrain	L	−12	−16	10	5.01	0.000018	894
Negative activation
MTG	R	54	−4	−11	−5.86	0.000001	1337
	L	−54	−1	−14	−4.99	0.000019	769
Hippocampus	R	30	−16	−11	−4.52	0.000076	400
Frontal eye fields	R	21	26	49	−3.91	0.000433	996
Angular gyrus	R	42	−61	22	−5.26	0.000009	1382
	L	−39	−67	25	−5.14	0.000012	1238
MPFC	L/R	0	44	1	−6.02	0.000001	19279
Ventral PCC/PCu/V2	L/R	0	−61	28	−7.86	<0.000001	31215

ROI: region of interest; aINS: anterior insula; SMA: supplementary motor area; PAG: periaqueductal gray; dlPFC: dorsolateral prefrontal cortex; M1: primary motor; S1: primary sensory; MTG: middle temporal gyrus; MPFC: medial prefrontal cortex; PCC: posterior cingulate cortex; PCu: precuneus; V2: secondary visual cortex; L: left; R: right; HC: healthy control; CP: patients with chronic pain.

Statistical strength, false discovery rate (FDR): q = 0.05, p < 0.0076, cluster size > 300 mm³. Coordinates were based on the stereotaxic atlas of Talairach.