Table 6.

Resultant regions of interest from subtraction analysis [(HC_OA − HC_Con) − (CP_OA − CP_Con)].

Name of ROIs	Side	Peak coordinates			t	p	Size (mm3)
		x	y	z
Putamen	L	−21	14	7	3.64	0.0003	256
ACC	L	−12	35	34	3.49	0.0005	1275
dlPFC	L	−30	11	37	3.41	0.0006	255
Brainstem	L/R	6	−25	−20	3.23	0.0012	227
mPFC	L/R	15	44	1	3.15	0.0017	706
NAc	L	−12	8	−8	3.05	0.0023	71
ACC	L/R	6	29	13	2.96	0.0030	297
Pars orbitalis	L	−30	26	−5	2.88	0.0039	104
Angular gyrus	R	42	−49	19	2.59	0.0095	88
dPCC	R	6	−64	19	2.59	0.0096	112
	L	−9	−58	25	2.45	0.0142	133

ROI: region of interest; HC: healthy control; CP: patients with chronic pain; OA: offset analgesia; Con: constant paradigm; ACC: anterior cingulate cortex; mPFC: medial prefrontal cortex; dlPFC: dorsolateral prefrontal cortex; NAc: nucleus accumbens; dPCC: dorsal posterior cingulate cortex; L: left; R: right.

Statistical threshold, p < 0.05; cluster size > 50 mm³. Coordinates were based on the stereotaxic atlas of Talairach.