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(A) Heatmap depicting PRO-seq, H3K27ac, and H3K4me3 near 1,520 TREs uing dREG from PRO-seq data. (B) Motifs enriched in 1,036 TREs that changed following 1 hr of GDNF treatment compared with TREs that have consistent levels. (C) Immunoblot analysis of p-ERK in B7TamS and G11TamR cells treatment with 10 ng/mL GDNF. (D) Schematic illustration of signaling pathways of tamoxifen resistant MCF-7 cells.
