Table 5. Antimicrobial resistance profiles and resistance determinants of 17 Shigella isolates co-resistant to cephalosporin and quinolone.
| Isolate | Antimicrobial resistance profile | β-Lactamases gene | QRDRs mutation | PMQR gene | Integron | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| blaOXA-1 | blaTEM-1 | blaCTX-M | gyrA | parC | qnrB/qnrS | IntI1 | IntI2 | hep74-51 | ||
| XJSF20 | CRO/CFZ/TIC/AMP/NOR/TE/C/STX | + | + | blaCTX-M-15 | S83L, D87N, H211Y | S80I | - | + | + | + |
| XJSF22 | CRO/CFP/CFZ/TIC/AMP/PIP/NOR/TE/ATM/C/STX | + | + | blaCTX-M-55 | S83L, D87G, H211Y | S80I | - | + | + | + |
| 2010048 | CRO/CFP/CFZ/TIC/AMP/PIP/NOR/TE/ATM/C/STX | + | + | blaCTX-M-55 | S83L, D87N, H211Y | S80I | - | + | + | + |
| 2011109 | CRO/CFP/CFZ/TIC/TIM/AMP/PIP/NOR/GN/TE/ATM/C/STX | + | + | blaCTX-M-55 | S83L, D87G, H211Y | S80I | - | + | + | + |
| 2012064 | CAZ/CRO/CFP/CFZ/TIC/AMP/NOR/TE/C | + | + | blaCTX-M-15 | S83L, D87G, H211Y | S80I | - | + | + | + |
| 2012076 | CRO/CFP/CFZ/TIC/TIM/AMP/PIP/LEV/NOR/TE/ATM/C/STX | + | + | blaCTX-M-15 | S83L, H211Y | S80I | - | + | + | + |
| 2012085 | CFZ/TIC/TIM/AMP/NOR/TE/C/STX | + | + | - | S83L, D87N, H211Y | S80I | - | + | + | + |
| 2012131 | CRO/CFP/CFZ/TIC/AMP/PIP/NOR/TE/ATM/C | + | + | blaCTX-M-55 | S83L, D87G, H211Y | S80I | - | + | + | + |
| 2012136 | CRO/CFP/CFZ/TIC/TIM/AMP/PIP/LEV/NOR/C | + | + | blaCTX-M-14 | S83L, D87N, H211Y | S80I | - | + | + | + |
| 2012262 | CRO/CFP/CFZ/TIC/TIM/AMP/PIP/NOR/TE/C | + | + | - | S83L, D87G, H211Y | S80I | - | + | + | + |
| 2013269 | CAZ/CRO/CFP/CFZ/TIC/TIM/AMP/PIP/LEV/NOR/TE/ATM/C/STX | + | + | blaCTX-M-15 | S83L, D87N, H211Y | S80I | - | + | + | + |
| 2013398 | CRO/CFP/CFZ/TIC/TIM/AMP/PIP/LEV/NOR/GN/TE/C/STX | + | + | blaCTX-M-14 | S83L, H211Y | S80I | - | + | + | + |
| 2013416 | CRO/CFP/CFZ/TIC/AMP/PIP/NOR/TE/ATM/C/STX | + | + | blaCTX-M-14, 64 | S83L, D87N, H211Y | S80I | - | + | + | + |
| 2014104 | CRO/CFP/CFZ/TIC/AMP/PIP/LEV/NOR/GN/TE/ATM/STX | - | - | blaCTX-M-15 | S83L, D87N, H211Y | S80I | - | + | - | - |
| 2014331 | CRO/CFP/CFZ/TIC/AMP/PIP/NOR/TE/ATM/C/STX | + | + | blaCTX-M-15 | S83L, D87N, H211Y | S80I | - | + | + | + |
| 2014351 | CRO/CFZ/TIC/AMP/LEV/NOR/TE/C/STX | + | - | blaCTX-M-14 | S83L, H211Y | S80I | - | - | + | + |
| 2014366 | CRO/CFZ/TIC/AMP/LEV/NOR/TE/C/STX | + | - | blaCTX-M-15 | S83L, D87N, H211Y | S80I | - | + | + | + |
AK, amikacin; AMP, ampicillin; ATM, aztreonam; CFZ, cefazolin; FEP, cefepime; CFP, cefoperazone; FOX, cefoxitin; CAZ, ceftazidime; CRO, ceftriaxone; C, chloramphenicol; GEN, gentamicin; IPM, imipenem; LEV, levofloxacin; NIT, nitrofurantoin; NOR, norfloxacin; PIP, piperacillin; SXT, trimethoprim/sulfamethoxazole; TE, tetracycline; TIC, ticarcillin; TIM, ticarcillin/clavulanic acid; TO, tobramycin.