Figure 1.

USP7 is upregulated in HCC tumor tissues. (A) RT-PCR results showed that the RNA level of USP7 was increased in HCC tumor tissues than that in adjacent normal liver tissues, and was positively correlated with the TNM stage. (B) Representative IHC result showed the negative protein expression of USP7 in normal liver tissues. (C) Representative IHC result showed the high protein level of USP7 in HCC tissues, which predominately located in the nucleus. (D) Statistical analysis of IHC scores in normal liver tissues and HCC tissues showed a significantly higher USP7 protein level in tumor tissues. Magnification: ×400. Data was presented as mean ±SD. * P<0.05 by Student’s t-test.