Fig 4. The pharmacological effects of a single and repeated dose of evocalcet in 5/6 Nx rats.

Vehicle or evocalcet (0.03, 0.1, 0.3, or 1 mg/kg) was orally administered to sham-operated and 5/6 Nx rats. A and B are the time courses of serum PTH (A) and Ca (B) levels after the first administration. C and D are the serum PTH (C) and Ca (D) levels before (day 0) and 24 h after evocalcet administration (days 7 and 14). The data are presented as the mean + S.E. n = 12/group. ^aP < 0.001 vs. Sham-vehicle group (Student’s t-test or Aspin-Welch test). ^bP < 0.05, ^cP < 0.01, and ^dP < 0.001 vs. 5/6 Nx-vehicle group (Steel test).