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. 2018 Apr 3;13(4):e0195316. doi: 10.1371/journal.pone.0195316

Table 2. Plasma concentrations of evocalcet after repeated oral administration to 5/6 nephrectomized rats.

Plasma concentration (ng/mL)
Dose Day 1 Day 7 Day 14
(mg/kg) 0.5 h 24 h 24 h 0.5 h 24 h
0.03 64.96 ± 14.58 4.696 ± 2.861 6.838 ± 6.788 51.46 ± 24.48 9.081 ± 6.781
0.1 204.2 ± 64.1 21.78 ± 16.45 53.46 ± 41.95 133.8 ± 71.2 29.24 ± 29.53
0.3 545.5 ± 154.9 90.48 ± 65.16 190.6 ± 105.3 686.9 ± 310.2 102.1 ± 97.1
1 1635 ± 733 285.7 ± 196.8 557.2 ± 460.0 1769 ± 1109 490.6 ± 402.2

The mean ± S.D. n = 12/group.