Table 2. Plasma concentrations of evocalcet after repeated oral administration to 5/6 nephrectomized rats.
Plasma concentration (ng/mL) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dose | Day 1 | Day 7 | Day 14 | ||||||||||||
(mg/kg) | 0.5 h | 24 h | 24 h | 0.5 h | 24 h | ||||||||||
0.03 | 64.96 | ± | 14.58 | 4.696 | ± | 2.861 | 6.838 | ± | 6.788 | 51.46 | ± | 24.48 | 9.081 | ± | 6.781 |
0.1 | 204.2 | ± | 64.1 | 21.78 | ± | 16.45 | 53.46 | ± | 41.95 | 133.8 | ± | 71.2 | 29.24 | ± | 29.53 |
0.3 | 545.5 | ± | 154.9 | 90.48 | ± | 65.16 | 190.6 | ± | 105.3 | 686.9 | ± | 310.2 | 102.1 | ± | 97.1 |
1 | 1635 | ± | 733 | 285.7 | ± | 196.8 | 557.2 | ± | 460.0 | 1769 | ± | 1109 | 490.6 | ± | 402.2 |
The mean ± S.D. n = 12/group.