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. 2018 Apr 3;13(4):e0195402. doi: 10.1371/journal.pone.0195402

Fig 4. Transient Treg depletion enhances B cell class switching in FV-infected mice.

Fig 4

B6.FOXP3-DTR mice were injected with 20,000 SFFU i.v. and left untreated or injected with 0.5 μg DT i.p. at 0, 3, and 6 dpi. Mice were bled and spleens were harvested at 2wpi or 3 wpi and total CD19+CD4- B cells were analyzed for IgM and IgD expression by flow cytometry. Each dot represents an individual mouse pooled from experiments with 2–6 mice per group. Lines indicate the mean of each group. ****P < .0001 as determined by ordinary one-way ANOVA with Tukey post-test for multiple comparisons.