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Polymorphic changes to the GRK5, ACTC1, and RYR2 loci in hPSCs. The nucleotide and translated single-letter amino acid sequences are shown for each locus. The targeting strategy introduces nonsynonymous changes as indicated. In each case, the gRNA, with PAM site boxed, spans an endogenous TTAA cassette insertion site, which eliminates the need for changes to spare the targeting vector from Cas9-mediated cleavage. Color images available online at www.liebertpub.com/scd
