Fig. 2.

Schematic representation of actin-related regulation of Hippo signaling. Actin filaments associated with tight and adherens junctions negatively regulate YAP/TAZ activity, whereas stress fibers associated with focal adhesions promote YAP/TAZ nuclear enrichment. Activation of RHO GTPases either by GPCRs or by mechanical stimuli at focal adhesions promote F-actin assembly and YAP/TAZ nuclear localization. F-actin capping and severing factors inhibit YAP/TAZ activity in a LATS-independent manner. AMOT and NF2 play important roles in cytoplasmic retention of YAP/TAZ and also facilitate YAP/TAZ phosphorylation by LATS.