Table 4. Cox univariate and multivariate analyses for the validation dataset (n=62).
| Variable | Univariate | Multivariate* | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| 18-GEP | 4.61 | 1.89-11.23 | 0.0008 | 9.28 | 1.22-70.29 | 0.0311 |
| WHO | ||||||
| II vs. I | 1.39 | 0.44-4.37 | 0.577 | 0.53 | 0.09-3.11 | 0.4857 |
| Mitotic index** | ||||||
| 3-4 vs. ≤ 2 | 1.24 | 0.23-6.78 | 0.8034 | 0.74 | 0.05-10.70 | 0.8228 |
| ≥5 vs. ≤ 2 | 5.29 | 1.32-21.23 | 0.0187 | 24.67 | 3.40-179.06 | 0.0015 |
| Simpson grade*** | ||||||
| 2 vs. 1 | 3.62 | 0.66-19.76 | 0.1378 | 1.45 | 0.17-12.52 | 0.7364 |
| 3 vs. 1 | 10.51 | 1.47-74.91 | 0.0189 | 2.96 | 0.08-107.56 | 0.5533 |
| 4 vs. 1 | 5.11 | 0.93-27.90 | 0.0599 | 4.54 | 0.60-34.08 | 0.1416 |
| Sex | ||||||
| M vs. F | 2.08 | 0.67-6.45 | 0.205 | 0.46 | 0.06-3.69 | 0.4619 |
| Location | ||||||
| Skull-base vs. Non skull-base | 1.84 | 0.58-5.82 | 0.298 | 1.14 | 0.17-7.76 | 0.8971 |
* 55 cases with complete data across all variables were introduced in the model.
**58 cases with complete data were introduced in the univariate model.
***59 cases with complete data were introduced in the univariate model.
Legend: 18-GEP, 18 gene expression profile model; CI, confidence interval; F, female; HR, hazard ratio; M, male.