. 2018 Mar 25;11(1):2–14. doi: 10.3400/avd.ra.17-00109

Table 2 Incidence rate of cardiovascular disease per 1,000 person-years based on overall and glucose tolerance status.

Study	Country	Glucose tolerance status	% Men	No. participants total	Endpoint	Sex	Categories	Rate per 1,000 person-years
General population
Suita Study Okamura et al. (2009)	Japan	NA	46	4,694	MI incidence			0.14
JALS-ECC study Tanabe et al. (2009)	Japan	NA	40	22,430	AMI incidence			0.65
JALS-ECC study Tanabe et al. (2009)	Japan	NA	40	22,430	Stroke incidence			3.29
According to glucose tolerance status
JPHC study Saito et al. (2009)	Japan	IFG/DM	36	31,192	CHD incidence	Men	NGT	1.0^†
							Borderline	1.37^†
							DM	2.06^†
						Women	NGT	0.30^†
							Borderline	0.29^†
							DM	1.02^†
Hisayama Study Doi et al. (2010)	Japan	NGT/IGT/DM	43	2,421	Ischemic stroke incidence	Men	FPG <5.6	5.4^†
							5.6–6.0	4.0^†
							6.1–6.9	4.7^†
							≥7.0	11.7^†
						Women	FPG <5.6	3.4^†
							5.6–6.0	3.9^†
							6.1–6.9	7.1^†
							≥7.0	9.6^†
					CHD incidence	Men	FPG <5.6	7.0^†
							5.6–6.0	4.7^†
							6.1–6.9	7.3^†
							≥7.0	9.9^†
						Women	FPG <5.6	1.4^†
							5.6–6.0	1.8^†
							6.1–6.9	2.5^†
							≥7.0	7.0^†
Large claim data Fujihara et al. (2017)	Japan	Prediabetes/DM	100	123,746	CAD incidence	Men aged 31–40 years	NGT	0.06
							Prediabetes	0.23
							DM	1.91
						Men aged 41–50 years	NGT	0.52
							Prediabetes	0.62
							DM	2.52
						Men aged 51–60 years	NGT	1.12
							Prediabetes	2.24
							DM	4.14
T2DM cohort
JDDM Yokoyama et al. (2011)	Japan	T2DM	63	2,984	CHD			4.4
JDDM Yokoyama et al. (2011)	Japan	T2DM	63	2,984	Stroke			3.1
JDCS Sone et al. (2011)	Japan	T2DM	53	1,771	MI	Men		4.95
					MI	Women		2.62
					Stroke	Men		8.70
					Stroke	Women		6.07
Western countries
UKPDS (1998)	UK	T2DM			MI		Intensive/conventional	14.7/17.4
UKPDS (1998)	UK	T2DM			Stroke incidence			5.6/5.0

^† Age adjusted. AMI: acute myocardial infarction; CAD: coronary artery disease; CHD: coronary heart disease; DM: diabetes mellitus; FPG: fasting plasma glucose; IFG: impaired fasting glucose; IGT: impaired glucose tolerance; JDCS: Japan Diabetes Complications Study Group; JDDM: Japan Diabetes Clinical Data Management Study Group; JPHC: Japan Public Health Center-based Prospective Study; MI: myocardial infarction; NA: not applicable; NGT: normal glucose tolerance; T2DM: type 2 diabetes mellitus; UKPDS: UK Prospective Diabetes Study