Table 2.
Summary of patients with strictly crossed corticospinal tract connectivity (Fig. 1, green outline) who met all other predefined criteria (Fig. 1, green outline; n = 26): (1) age at time of visit; (2); sex (3) age of first reported seizure; (4) seizure onset zone; (5) underlying etiology; (6) seizure semiology as defined by the International League Against Epilepsy 2017 criteria; (7) seizure frequency classified by more than one seizure per day, less than one seizure per day but multiple seizures a week/per month, and one to two seizures per year; (8) presence or absence of a fine motor deficit in the dominant hand; (9) metrics of patient verbal IQ; and (10) nonverbal IQ.
| Age (yrs) |
Sex (F/M) |
Handedness (R/L/A) |
Age of seizure onset (yrs) |
Seizure onset zone |
Etiology | Semiology at onset | Frequency | Fine motor deficit? (Y/N) |
Verbal IQ |
Nonverbal IQ |
|---|---|---|---|---|---|---|---|---|---|---|
| 8 | M | R | 4 | Right centroparietal | FCD | Focal motor | >Daily | Y | 108 | 112 |
| 10 | M | R | 7 | Right anterior temporal | FCD | Focal motor | Weekly to monthly | N | 63 | 85 |
| 11 | M | R | 6 | Right frontal | Porencephalic cyst | Dyscognitive | Weekly to monthly | N | 79 | 95 |
| 12 | F | R | 2 | Left temporal | Sturge–Weber syndrome |
|
Weekly to monthly | Y | 102 | 117 |
| 12 | F | R | 9 | Right frontal | FCD | Dyscognitive | Weekly to monthly | N | 100 | 97 |
| 12 | F | R | 2.2 | Left frontoparietal | Unknown | GTC | >Daily | N | 114 | 104 |
| 12 | F | R | 3 | Left frontal parietal | Unknown | Focal motor | >Daily | N | 130 | 128 |
| 12 | F | R | 4 | Left temporal | Unknown | Focal motor | Weekly to monthly | Y | 89 | 98 |
| 12 | M | R | 11 | Left frontoparietal | Stroke | Focal motor | >Daily | Y | 78 | 74 |
| 12 | M | L | 0 | Right temporal | Unknown |
|
Weekly to monthly | N | 121 | 112 |
| 13 | M | R | 7 | Left temporal | FCD | Dyscognitive | >Daily | N | 95 | 84 |
| 14 | M | R | 6 | Left temporal occipital | Unknown |
|
>Daily | Y | 95 | 91 |
| 15 | F | L | 6 | Left parietal | Unknown | Focal motor | Weekly to monthly | N | 76 | 92 |
| 15 | F | R | 1 | Left temporal | Unknown |
|
Weekly to monthly | Y | 78 | 82 |
| 15 | F | R | 3 | Left frontal | Unknown | Focal motor | >Daily | Y | 84 | 79 |
| 17 | M | R | 6 | Left frontal | MCD | Focal sensory | Weekly to monthly | Y | 105 | 104 |
| 17 | M | L | 12 | Right parietal | FCD | Focal motor | Yearly | N | 103 | 94 |
| 17 | F | R | 1 | Right frontal | FCD | Focal motor | Weekly to monthly | N | 134 | 82 |
| 17 | M | R | 10 | Left frontal | Cerebitis; meningitis |
|
>Daily | Y | 87 | 75 |
| 17 | F | R | 4 | Right frontal medial | Stroke |
|
Weekly to monthly | Y | 126 | 117 |
| 17 | M | L | 7 | Left temporal | Stroke | Dyscognitive | Weekly to monthly | N | 95 | 105 |
| 18 | M | R | 9 | Left parietal | Unknown | Focal motor | >Daily | Y | 105 | 105 |
| 18 | M | R | 0 | Left parietal | FCD | Focal sensory | >Daily | Y | 110 | 75 |
| 22 | F | R | 14 | Right frontal | TBI | Dyscognitive | Weekly to monthly | Y | 72 | 79 |
| 22 | F | A | 1 | Left frontal | FCD | focal motor | >Daily | Y | 82 | 71 |
| 23 | F | L | 10 | Left central parietal | Stroke |
|
>Daily | N | 93 | 104 |
Abbreviations: years (yrs), female (F), male (M), right handed (R), left handed (L), ambidextrous (A), presence of fine motor deficit (Y), absence of fine motor deficit (N), focal cortical dysplasia (FCD), multiple focal cortical dysplasia (MCD), traumatic brain injury (TBI), generalized tonic–clonic (GTC).