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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Mol Cancer Res. 2018 Jan 12;16(4):669–681. doi: 10.1158/1541-7786.MCR-17-0321

Figure 1. Enriched miR-888 cluster expression in metastatic PC3-ML prostate cells & their secreted exosomes, and in EPS urine exosomes from high-grade prostate cancer patients.

Figure 1

A, Schematic representation of the miR-888 cluster on human chromosome Xq27.3 and sequence homology shared between the miR-743 (grey) and the miR-891 (white) miRNA families. B, miR-888 cluster expression was measured using qRT-PCR on a panel of human prostate cell lines differing in their metastatic status and response to androgen. C, Comparison of miRNA levels by qRT-PCR in metastatic PC3-ML prostate cancer cells & exosomes relative to non-aggressive PC3-N; and D, in EPS urine-derived exosomes from high-grade and low-grade prostate cancer patients relative to non-cancer patients. Results were normalized using snoRNA RNU48 (cells) or U6 snRNA (exosomes).