Figure 3.

Remodelling of “high-lipid” SAA complexes by PLA₂ and its effects on fibrillation. (A) Non-denaturing PAGE of the complexes that have been incubated at 37 °C for 3 h with (+PLA₂) or without PLA₂ (-PLA₂). Intact free SAA is shown for comparison. Gel filtration data (Fig S6) ascertain these results. (B) TEM of “high-lipid” SAA:POPE complexes hydrolysed with PLA₂; the images were taken before (0 h) and after 72 h incubation at 37 °C (72 h).